TRH Thyrotropin (Protirelin) 20mg – Peptide for Research Use

TRH (Thyrotropin-Releasing Hormone), also known as Protirelin, is a naturally occurring peptide hormone produced in the hypothalamus. It plays a key role in regulating thyroid function and has been the subject of growing interest due to its potential benefits in mental health, aging, motor control, and neurological function.

What is TRH (Protirelin)?

TRH is a tripeptide (Pyr-His-Pro) that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin from the anterior pituitary gland. Its role in regulating the endocrine system makes it valuable for scientific exploration into hormone balance, mood regulation, and metabolic health. Researchers have studied TRH for its possible antidepressant and anti-suicidal effects, as well as its impact on aging and oxidative stress.

Key Research Areas

1. Mood and Mental Health Support

Research dating back to the 1970s has shown that TRH may reduce symptoms of depression and suicidal thoughts. In clinical settings, patients treated with TRH—whether intrathecally, intravenously, or intranasally—have shown significant improvements in mood. Notably, studies suggest that nighttime administration may enhance the peptide’s effectiveness, possibly due to alignment with natural circadian rhythms.

2. Motor Learning and Coordination

Animal studies suggest that TRH is active in the cerebellum—the brain region responsible for coordination and balance. Mice without TRH showed delayed motor learning, while those supplemented with TRH learned tasks faster. This suggests TRH may play a role in enhancing motor memory and could have implications for neurodegenerative disease research.

3. Opioid Overdose and Respiratory Support

Recent studies indicate TRH could be a promising agent in treating opioid overdoses. It has shown the ability to stimulate breathing and increase blood pressure without blocking pain relief—unlike traditional treatments like naloxone. This makes it a potential alternative or complement in emergency overdose interventions.

4. Applications in Trauma and Shock

TRH analogues, such as Taltirelin, have been tested in models of hemorrhagic shock. Results show improvements in blood pressure, oxygen levels, and acid-base balance—highlighting potential benefits in emergency medicine and trauma care.

5. Impact on Aging and Organ Protection

Animal research indicates that TRH may help protect against oxidative damage in organs such as the kidneys and testes. This protection may help slow age-related decline in organ function. TRH has also been studied in the context of Alzheimer’s disease, where it may help preserve brain function by regulating key cellular processes.

Molecular Information

• Sequence: Pyr-His-Pro

• Molecular Formula: C₁₆H₂₂N₆O₄

• Molecular Weight: 362.39 g/mol

• CAS Number: 24305-27-9

• Synonyms: Protirelin, Thyroliberin, Relefact, Lopremane

Safety and Availability

Protirelin has demonstrated a favorable safety profile in animal studies, with high oral and subcutaneous bioavailability. However, TRH is strictly intended for scientific and educational research purposes only. It is not approved for human or veterinary use. All buyers must be qualified professionals or licensed researchers.

Scientific Contributions

This product’s research background has been enriched by the work of numerous scientists, including Dr. E. Logan, M.D. and Professor Walter Pierpaoli, a pioneer in neuroimmunomodulation and aging science. While their studies provide valuable insights into TRH’s potential, these researchers do not endorse or promote the use or sale of this peptide for any purpose outside scientific investigation.

Important Notice

All information provided is for educational and research reference only. TRH (Protirelin) sold by Amino Pharm is not intended for human or animal consumption. It is intended strictly for in-vitro and laboratory use.